Also known as GHRP-6 Peptide, GHRP-6, Growth Hormone Releasing Peptide-6; GHRP6; Growth Hormone Releasing Hexapeptide
One of the more potent stimulators of Natural Growth Hormone Release is GHRP-6. Classified as a Hexapeptide, it helps to enhance energy metabolism and induces hunger. GHRP-6 along with other Growth Hormone Releasing Peptides are used to treat Growth Hormone (GH) deficiencies, obesity and so on. From studies, it has been observed that HGH peptides can boost stamina and strength, and at the same time reduce body fat while increasing lean muscle mass.
Chemical Description of GHRP 6
Molecular formula: C46H56N12O6
Molar Mass: 873.014
CAS number: 87616-84-0
History of GHRP 6
The search for the Growth Hormone Releasing Hormone has been on for quite some time, but it was in 1982 that it was identified. Researchers were able to discover GHRP-6 and GHRP-2, out of all GH-Releasing Peptides, had a specific way of acting that was facilitated by receptors different from those of Growth Hormone Releasing Hormone. In addition, it was also observed that natural GHRH, acted in synergy with GHRP-6 and GHRP-2 to create a large dose of Growth Hormone in both laboratory animals and humans.
The 1980s brought about the development of the GHRP-6. It was tagged “the first highly potent GH-Releasing Peptide.” It is known as the first member of the class called Growth Hormone Secretagogues. In its structure, GHRP-6 comprises 6 amino acids namely; L-Lysine, D-Tryptophan, L-Histidine, L-Alanine, D-Phenylalanine, L-Tryptophan. The “L” in front of any amino acids signifies that it occurs naturally while the “D” signifies it doesn’t occur naturally and it specifies that the amino acid is isomeric of its naturally occurring “L” counterpart. In the nomenclature, the “L” is not attached to the name of amino acids only the “D.” GHRP-6 consists of both isomeric and natural amino acids; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. The sequence helps to initiate the secretion of Growth Hormone release and at the same time prevent the secretion of a hormone that inhibits the release of Growth Hormone called Somatostatin.
Studies on GHRP-6 Peptide
Studies have shown that GHRP-6 is more potent than GHRH when used in monkeys, and it also shows more effective when used in combination with other peptides. An investigation revealed that GHrP-6 acts naturally on both pituitary and hypothalamic sites. Experiments were carried out on primary pituitary cells of rats. The maximum and minimum stimulation of GHRP-6 concentration was 7 x 10-9M and 10-7M respectively.
Another study revealed that GHRP-6 mainly targets the Hypothalamus in both laboratory animals and humans. From the study, it showed that somatostatin inhibited the actions of GHRP-6, and prevented the GH-release. Furthermore, the actions of somatostatin on the GRF neurons, induced by GHRP-6, was observed via receptors close to the GRF. This study proved that GHRP-6 stimulates GH release from somatotrophs via various receptors.
The full extent of how efficient the Growth Hormone depends on the medium of the experiment. For instance, GH secretion reduces with obesity in humans. However, GHRP-6 in one experiment, showed an increase in obesity. Although obesity can be considered as an efficiency factor of GHRP-6, the main factors are sex and age.
GHRP-6 and the Growth Hormone Secretagogue
GHRP-6 is not a direct offspring of GHRH. It is an artificial activator of GHS-R (Growth Hormone Secretagogue Receptor). GHRP 6 is classified as a “Growth Hormone Secretagogue” along with other synthetic compounds like Ghrelin (which is an endogenous ligand, that binds to the GHS-R). It helps to induce hunger by increasing appetite for food by stimulating the release of Ghrelin. It also plays a role in encouraging Growth Hormone Release. Subsequently, the more Growth Hormone is released, the more the liver secretes IGF-1. This can lead to a reduction in body fat, and an increase in muscle build.
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